Retinal Diseases and Treatments

Retinal diseases such as age-related macular degeneration and diabetic retinopathy damage the light-sensitive tissue at the back of the eye, progressively destroying central vision in tens of millions of people worldwide. Researchers study how the retinal pigment epithelium breaks down under oxidative stress, how abnormal blood vessel growth driven by vascular endothelial growth factor erodes retinal structure, and how genetic variants like the complement factor H polymorphism raise individual disease risk. Intravitreal injections that block this growth factor have transformed treatment over the past two decades, yet a substantial fraction of patients respond incompletely, and the mechanisms linking choroidal blood flow changes to disease progression remain incompletely understood. Current work aims to clarify these gaps using high-resolution imaging technologies and to develop therapies that go beyond symptom control toward genuine tissue preservation or regeneration.

Works

106,821

Total citations

2,036,573

Keywords

Macular DegenerationRetinal Pigment EpitheliumDiabetic RetinopathyOxidative StressVascular Endothelial Growth FactorChoroidal Thickness