Renal cell carcinoma treatment
Renal cell carcinoma, the most common form of kidney cancer in adults, frequently spreads to the lungs, making its intersection with pulmonary medicine a critical area of clinical concern. Researchers are working to understand how molecular and genetic characteristics of tumors predict disease course, guide decisions about nephron-sparing surgery, and determine which patients are most likely to respond to immunotherapy or targeted agents. Despite meaningful progress in systemic treatments, durable responses in metastatic disease remain difficult to achieve, and identifying reliable biomarkers that distinguish responders from non-responders is an active and unresolved challenge. Work is also ongoing to refine clinical guidelines that integrate new molecular data with established prognostic factors, aiming to move treatment decisions closer to true personalization.
- Works
- 90,791
- Total citations
- 1,167,609
- Keywords
- Renal Cell CarcinomaMetastaticTreatmentTherapyPrognostic FactorsMolecular Characterization
Top papers in Renal cell carcinoma treatment
Ordered by total citation count.
- Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review↗ 15,286OA
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing↗ 7,794OA
- Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma↗ 5,885OA
- Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma↗ 5,754OA
- Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma↗ 4,783OA
- Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma↗ 4,639OA
- Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial↗ 3,712
- Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma↗ 3,647
- Comprehensive molecular characterization of clear cell renal cell carcinoma↗ 3,538OA
- EAU Guidelines on Renal Cell Carcinoma: 2014 Update↗ 3,458OA
- Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma↗ 3,399OA
- Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial↗ 3,012
Active researchers
Top authors in this area, ranked by h-index.