Lung Cancer Diagnosis and Treatment
Lung cancer kills more people worldwide than any other cancer, making accurate diagnosis and effective treatment among the most consequential problems in medicine. Clinicians and researchers work to detect tumors as early as possible — often through low-dose CT screening or positron emission tomography — and then stage them precisely to determine whether surgery, stereotactic body radiation therapy, chemotherapy, or some combination offers the best chance of survival. Open questions center on how to manage the vast number of small pulmonary nodules that screening programs inevitably uncover, most of which are benign, and on identifying which patients with early-stage disease will benefit from adjuvant therapy after their primary treatment. Advances in tumor biology and imaging are steadily refining these decisions, but the gap between what screening can detect and what treatment can reliably cure remains a defining challenge of the field.
- Works
- 132,434
- Total citations
- 1,610,592
- Keywords
- Lung CancerCT ScreeningRadiotherapyChemotherapyTumor StagingAdjuvant Therapy
Top papers in Lung Cancer Diagnosis and Treatment
Ordered by total citation count.
- The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology↗ 16,075
- Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib↗ 11,545
- Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening↗ 11,105OA
- Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer↗ 10,181OA
- Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer↗ 9,502OA
- Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma↗ 8,282OA
- Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer↗ 6,689OA
- Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial↗ 6,556
- Deep Convolutional Neural Networks for Computer-Aided Detection: CNN Architectures, Dataset Characteristics and Transfer Learning↗ 5,833OA
- Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer↗ 5,784OA
- Gefitinib or Chemotherapy for Non–Small-Cell Lung Cancer with Mutated EGFR↗ 5,584
- Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial↗ 5,545OA
Active researchers
Top authors in this area, ranked by h-index.