Prostate Cancer Treatment and Research

Prostate cancer becomes life-threatening primarily when it spreads beyond the gland and develops resistance to treatments that suppress androgen signaling, the hormonal pathway most tumors depend on to grow. Researchers are working to understand why cancer cells eventually evade hormone therapy — through mutations in the androgen receptor, gene fusions, and other molecular changes — and how genomic profiling can identify which patients are most vulnerable to specific drug failures. Second-generation antiandrogens and emerging immunotherapy approaches have extended survival in metastatic disease, yet durable responses remain elusive for many patients. Open questions center on predicting and overcoming resistance at the molecular level, and on determining which combinations of targeted therapy, immunotherapy, and genomic-guided treatment will prove most effective across the diverse genetic landscapes individual tumors present.

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Keywords

Prostate CancerAndrogen ReceptorGenomic ProfilingHormone TherapyMetastatic Prostate CancerImmunotherapy