Prostate Cancer Diagnosis and Treatment

Prostate cancer is the most commonly diagnosed solid malignancy in men across much of the world, and understanding how to detect it early and treat it effectively has occupied clinicians and researchers for decades. Work in this area spans the full clinical arc of the disease: from PSA-based screening and MRI-guided biopsy through histological grading with the Gleason system, to treatment with radiation therapy, surgery, or androgen suppression, and on to tracking long-term survival in diverse patient populations. A central tension driving current research is how to distinguish slow-growing tumors that may never threaten a patient's life from aggressive cancers that demand prompt intervention—overdiagnosis and overtreatment carry real costs in quality of life. Active directions include refining genomic and imaging biomarkers to sharpen that distinction, optimizing the sequencing of androgen suppression with other therapies, and building clearer clinical guidelines for men whose disease recurs after initial treatment.

Works

123,964

Total citations

1,967,308

Keywords

Prostate CancerScreeningRadiation TherapyGleason GradingMRI ImagingAndrogen Suppression