Migraine and Headache Studies

Migraine is a complex neurological disorder affecting roughly one billion people worldwide, characterized by recurring episodes of severe headache alongside sensory disturbances that can be profoundly disabling. Research into its mechanisms has implicated a cascade of biological events — including cortical spreading depression, activation of the trigeminal nerve, and the release of calcitonin gene-related peptide — that together drive the pain and associated symptoms, though precisely how these processes initiate and sustain an attack remains an open question. The development of CGRP-targeted therapies has marked a significant advance in both prevention and acute treatment, yet a substantial portion of patients with chronic migraine still do not respond adequately, motivating ongoing work into genetic susceptibility, central sensitization, and the relationship between migraine and broader psychiatric conditions such as depression and anxiety. Understanding why some individuals progress from episodic to chronic migraine, and how neurological and psychological factors interact in that transition, represents one of the most active and consequential directions in the field.

Works

100,938

Total citations

1,428,827

Keywords

MigraineHeadache DisordersNeurological DisordersCalcitonin Gene-Related PeptideChronic MigraineBrain Activation