Fatty Acid Research and Health
Omega-3 fatty acids are a class of polyunsaturated fats found in fish, certain plant oils, and marine algae, and researchers study how dietary intake of these compounds shapes human health across the lifespan, from fetal brain development to age-related cardiovascular disease. Once consumed, omega-3s are metabolized into bioactive lipid mediators—including docosahexaenoic acid (DHA) and signaling molecules called resolvins—that help regulate inflammation, a process now understood to underlie conditions ranging from atherosclerosis to neurodegeneration. Central questions driving current work include how much omega-3 intake is sufficient to produce measurable clinical benefit, why individuals respond so differently to supplementation, and how modern Western diets, which tend to be low in omega-3s and high in competing omega-6 fats, shift the body's inflammatory balance in ways that promote chronic disease. Ongoing research is working to map the precise molecular pathways through which these fatty acids act, with the goal of giving clinicians clearer, evidence-based guidance for dietary recommendations and therapeutic use.
- Works
- 83,289
- Total citations
- 2,117,093
- Keywords
- Omega-3 Fatty AcidsCardiovascular DiseaseInflammationDietary IntakeFatty Acid MetabolismNeurodevelopment
Top papers in Fatty Acid Research and Health
Ordered by total citation count.
- A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION↗ 48,918
- A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION↗ 22,918
- A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis↗ 4,706OA
- Metabolism of Isolated Fat Cells↗ 4,423OA
- The importance of the ratio of omega-6/omega-3 essential fatty acids↗ 4,124
- Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial↗ 3,819
- Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease↗ 3,688
- Wine, alcohol, platelets, and the French paradox for coronary heart disease↗ 3,612
- Coronary heart disease: seven dietary factors↗ 3,562
- Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease↗ 3,456OA
- HMG-1 as a Late Mediator of Endotoxin Lethality in Mice↗ 3,390
- Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells↗ 3,256OA
Active researchers
Top authors in this area, ranked by h-index.