Cancer and Skin Lesions

Cutaneous adnexal neoplasms are tumors arising from the skin's accessory structures — sweat glands, hair follicles, and sebaceous glands — and range from benign growths like trichoepithelioma and pilomatricoma to malignancies such as extramammary Paget's disease, which can signal an underlying internal cancer. Accurate diagnosis depends heavily on immunohistochemical staining to distinguish these lesions from one another and from metastatic disease, while surgical approaches like Mohs micrographic surgery aim to clear tumor margins while sparing healthy tissue. Researchers are actively investigating how mutations in genes such as CYLD, linked to cylindromatosis, drive tumor development and syndromic presentations affecting multiple adnexal structures. Understanding the molecular landscape of these neoplasms could clarify why some remain localized while others behave aggressively, and may eventually point toward targeted therapies beyond surgery.

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Keywords

Extramammary Paget's DiseaseAdnexal NeoplasmsPaget's DiseaseCylindromatosis GeneMohs Micrographic SurgeryImmunohistochemistry