Skin Protection and Aging
Prolonged exposure to ultraviolet radiation accelerates skin aging by triggering oxidative stress, degrading collagen through enzymes called matrix metalloproteinases, and accumulating DNA damage that can progress toward skin cancer. Dermatologists studying these processes aim to understand exactly how photoaging unfolds at the cellular level and how interventions—ranging from broad-spectrum sunscreens to topical antioxidants—can slow or partially reverse that damage. Active research is working to clarify which antioxidant compounds most effectively neutralize reactive oxygen species in living skin, and how protection strategies might be optimized across different skin types and cumulative sun exposure histories. The stakes are substantial, given that skin cancer remains one of the most commonly diagnosed cancers globally and that much of its burden is considered preventable.
- Works
- 73,305
- Total citations
- 907,287
- Keywords
- UV RadiationOxidative StressSkin CancerPhotoagingAntioxidantsCollagen Production
Top papers in Skin Protection and Aging
Ordered by total citation count.
- A biomarker that identifies senescent human cells in culture and in aging skin in vivo.↗ 7,477OA
- Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin↗ 7,309OA
- The Validity and Practicality of Sun-Reactive Skin Types I Through VI↗ 3,365
- Accelerated telomere shortening in response to life stress↗ 2,998
- Photodynamic therapy and anti-tumour immunity↗ 2,673OA
- The role of senescent cells in ageing↗ 2,636
- The Optics of Human Skin↗ 2,442
- Cellular senescence in aging and age-related disease: from mechanisms to therapy↗ 2,356OA
- Cellular senescence in ageing: from mechanisms to therapeutic opportunities↗ 2,237OA
- Epidemiology and Risk Factors of Urothelial Bladder Cancer↗ 2,199
- Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation↗ 2,006
- A systematic review of worldwide incidence of nonmelanoma skin cancer↗ 1,936
Active researchers
Top authors in this area, ranked by h-index.