Bacterial Genetics and Biotechnology
Bacterial genetics and biotechnology examines how bacteria regulate gene expression, maintain internal balance, and respond to environmental stress at the molecular level. Understanding these mechanisms has become increasingly urgent as antibiotic resistance spreads globally, forcing researchers to map the precise signals and molecular switches that allow bacteria to survive drug exposure, persist in hostile conditions, and adapt their membrane composition and metabolism on the fly. Active areas of investigation include how small RNAs orchestrate rapid shifts in gene expression, how bacteria manage iron availability as both a nutrient and a toxin, and how signal transduction pathways coordinate cell-wide responses to threats. Resolving these questions could reveal new targets for antimicrobials and inform the engineering of bacterial systems for medical, agricultural, and industrial applications.
- Works
- 136,458
- Total citations
- 2,685,071
- Keywords
- Bacterial PhysiologyGene RegulationAntibiotic ResistanceCellular HomeostasisSignal TransductionBacterial Genetics
Top papers in Bacterial Genetics and Biotechnology
Ordered by total citation count.
- DNA sequencing with chain-terminating inhibitors↗ 69,235OA
- MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability↗ 47,370OA
- Prokka: rapid prokaryotic genome annotation↗ 19,148
- Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors↗ 15,161
- One-step inactivation of chromosomal genes in <i>Escherichia coli</i> K-12 using PCR products↗ 15,099OA
- A rapid alkaline extraction procedure for screening recombinant plasmid DNA↗ 14,872OA
- The RAST Server: Rapid Annotations using Subsystems Technology↗ 11,734OA
- Studies on transformation of Escherichia coli with plasmids↗ 11,259
- SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling↗ 11,234
- Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase↗ 10,294
- The Phyre2 web portal for protein modeling, prediction and analysis↗ 10,191OA
- RNA-Guided Human Genome Engineering via Cas9↗ 9,320OA
Active researchers
Top authors in this area, ranked by h-index.