Tuberculosis Research and Epidemiology
Tuberculosis is a bacterial infection caused by *Mycobacterium tuberculosis* that kills more than a million people each year, making it one of the deadliest infectious diseases despite being both treatable and preventable. Researchers study how the bacterium evades the human immune system, how drug-resistant strains emerge and spread, and why existing diagnostics often fail in the low-resource settings where the disease is most common. The only licensed vaccine, BCG, offers inconsistent protection in adults, so a major active direction is understanding the molecular dialogue between pathogen and host well enough to design more effective immunizations and shorter treatment regimens. Alongside these clinical questions, epidemiologists track the global genetic diversity of circulating strains to map transmission networks and anticipate where resistance is likely to intensify.
- Works
- 239,145
- Total citations
- 2,627,360
- Keywords
- TuberculosisMycobacterium tuberculosisDrug ResistanceImmune ResponseDiagnosisVaccine
Top papers in Tuberculosis Research and Epidemiology
Ordered by total citation count.
- Global tuberculosis report (2014)↗ 13,180
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence↗ 7,847OA
- An Official ATS/IDSA Statement: Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial Diseases↗ 6,049
- Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis↗ 5,985OA
- Drug repurposing: progress, challenges and recommendations↗ 4,551
- Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent↗ 3,694OA
- Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Designs↗ 3,527OA
- Global Burden of Tuberculosis↗ 2,963
- Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology↗ 2,881OA
- Genes required for mycobacterial growth defined by high density mutagenesis↗ 2,578OA
- The Growing Burden of Tuberculosis↗ 2,560
- An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.↗ 2,467OA
Active researchers
Top authors in this area, ranked by h-index.