Health SciencesMedicineInfectious Diseases

Tuberculosis Research and Epidemiology

Tuberculosis is a bacterial infection caused by *Mycobacterium tuberculosis* that kills more than a million people each year, making it one of the deadliest infectious diseases despite being both treatable and preventable. Researchers study how the bacterium evades the human immune system, how drug-resistant strains emerge and spread, and why existing diagnostics often fail in the low-resource settings where the disease is most common. The only licensed vaccine, BCG, offers inconsistent protection in adults, so a major active direction is understanding the molecular dialogue between pathogen and host well enough to design more effective immunizations and shorter treatment regimens. Alongside these clinical questions, epidemiologists track the global genetic diversity of circulating strains to map transmission networks and anticipate where resistance is likely to intensify.

Works
239,145
Total citations
2,627,360
Keywords
TuberculosisMycobacterium tuberculosisDrug ResistanceImmune ResponseDiagnosisVaccine

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