Antifungal resistance and susceptibility

Antifungal resistance and susceptibility research examines how fungal pathogens — including *Candida*, *Aspergillus*, and *Mucorales* species — respond to the limited arsenal of available antifungal drugs, and how resistance emerges through mechanisms such as target-site mutations, efflux pump upregulation, and the formation of drug-tolerant biofilms. These infections disproportionately threaten immunocompromised patients, including those undergoing chemotherapy or organ transplantation, and carry mortality rates that remain stubbornly high despite treatment. Epidemiologists and clinicians are tracking the global spread of resistant strains like *Candida auris* while working to standardize susceptibility breakpoints that can reliably guide therapy across diverse clinical settings. A central open question is how to detect resistance early enough to matter — and whether combination regimens or newer antifungal classes can overcome resistance without adding unacceptable toxicity.

Works

121,194

Total citations

2,350,671

Keywords

Invasive Fungal InfectionsCandidiasisAspergillosisAntifungal TherapyMucormycosisBiofilm Formation