Antifungal resistance and susceptibility

Antifungal resistance and susceptibility research examines how fungal pathogens—such as *Candida*, *Aspergillus*, and *Mucor* species—evade or withstand the drugs used to treat them, and how clinicians can reliably detect that resistance before choosing a therapy. These infections carry disproportionate mortality among immunocompromised patients, including those undergoing chemotherapy or organ transplantation, where a delayed or ineffective treatment choice can be fatal. A central challenge is that the antifungal drug classes available remain few compared to antibiotics, and mechanisms like biofilm formation and efflux pump upregulation continue to erode the effectiveness of established agents. Researchers are actively working to improve susceptibility testing standards, track the global spread of resistant strains such as *Candida auris*, and identify new therapeutic targets before the existing arsenal is further compromised.

Works

119,421

Total citations

2,313,337

Keywords

Invasive Fungal InfectionsCandidiasisAspergillosisAntifungal TherapyMucormycosisBiofilm Formation