Sepsis Diagnosis and Treatment

Sepsis occurs when the body's response to infection spirals into a state of widespread inflammation and organ dysfunction, and it remains one of the leading causes of death in hospital intensive care units worldwide. Epidemiologists and critical care researchers study how frequently sepsis arises, which patient populations are most vulnerable, how reliably clinicians can identify it early, and whether treatments like antibiotics and fluid resuscitation are being applied in ways that genuinely improve survival. A persistent challenge is that sepsis has no single definitive diagnostic test, so researchers are actively working to validate biomarkers — measurable biological signals in blood or tissue — that could flag deterioration before it becomes irreversible. Equally contested are the predictive models used to estimate a patient's risk of death, since a model that performs well in one hospital population often loses accuracy when applied elsewhere, pushing the field toward more generalizable and dynamically updated approaches.

Works

106,561

Total citations

1,802,087

Keywords

SepsisSeptic ShockEpidemiologyManagementPrognostic ModelsInfection