Paraoxonase enzyme and polymorphisms

Paraoxonase (PON1) is a calcium-dependent enzyme carried on high-density lipoproteins (HDL) that helps protect lipids from oxidative damage, placing it at the intersection of antioxidant defense and cardiovascular biology. Because oxidized LDL is a key driver of atherosclerotic plaque formation, researchers have worked to understand how PON1 activity modulates that process and why individuals vary so substantially in their level of protection. Much of that variation traces to genetic polymorphisms — particularly at positions Q192R and L55M — which alter both enzyme activity and substrate specificity in ways that appear to influence cardiovascular disease risk across populations. Current work is clarifying how these polymorphisms interact with diet, inflammation, and other HDL-associated proteins, and whether boosting or mimicking PON1 function could translate into a practical therapeutic strategy.

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10,232

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196,886

Keywords

ParaoxonaseAtherosclerosisOxidative StressAntioxidantCardiovascular DiseaseGenetic Polymorphisms