Advanced Glycation End Products research

When glucose reacts non-enzymatically with proteins and lipids over time, it generates a chemically diverse family of molecules called Advanced Glycation End Products, or AGEs, whose accumulation drives much of the tissue damage seen in diabetes and aging. Researchers in this area work to understand how AGEs and related danger signals—particularly the protein HMGB1—activate receptors such as RAGE and Toll-like receptors to trigger oxidative stress and chronic inflammation, with mitochondrial superoxide production emerging as a key amplifier of that damage cascade. A central open question is how these interconnected pathways interact across different cell types and organs to produce the spectrum of diabetic complications, from neuropathy to cardiovascular disease. Active investigation is also focused on whether blocking specific nodes in the AGE–RAGE–HMGB1 axis can interrupt disease progression without disrupting the normal signaling functions these molecules serve.

Works

47,579

Total citations

1,238,876

Keywords

Advanced Glycation End ProductsHMGB1Oxidative StressInflammationRAGEDiabetes