Advanced Glycation End Products research

When glucose reacts non-enzymatically with proteins and lipids over time, it produces a chemically diverse family of molecules known as Advanced Glycation End Products, or AGEs, which accumulate in tissues and drive much of the cellular damage seen in diabetes and aging. Researchers in this area investigate how AGEs and related danger signals like HMGB1 activate the receptor RAGE and toll-like receptors, triggering inflammatory cascades and mitochondrial superoxide production that progressively injure blood vessels, nerves, and kidneys. A central open question is how these overlapping signaling pathways interact at the molecular level — particularly how oxidative stress and inflammation reinforce each other in a self-sustaining cycle that persists even when blood glucose is brought under control. Clarifying these mechanisms could eventually point toward therapeutic targets that interrupt diabetic complications at a much earlier stage than current treatments allow.

Works

47,267

Total citations

1,229,710

Keywords

Advanced Glycation End ProductsHMGB1Oxidative StressInflammationRAGEDiabetes