Genomics and Phylogenetic Studies

Genomics and phylogenetic studies use DNA and RNA sequence data to reconstruct the evolutionary relationships among organisms, characterize the functional output of genomes, and catalog genetic variation within and across species. Techniques such as RNA sequencing and transcript quantification reveal which genes are active under particular conditions, while sequence alignment and genome annotation transform raw sequencing reads into interpretable biological information. At larger scales, metagenomics assembly extends these methods to entire microbial communities sampled directly from environmental sources, without the need to culture individual organisms. Active challenges include improving the accuracy of phylogenetic trees when genomes evolve at uneven rates, and developing more robust statistical frameworks for quantifying transcript abundance in the face of sequencing noise and complex alternative splicing.

Works

568,620

Total citations

7,531,970

Keywords

RNA-seqsequence alignmentphylogenetic analysisgenome annotationtranscript quantificationmetagenomics assembly