Genomics and Phylogenetic Studies

Genomics and phylogenetic studies use DNA and RNA sequence data to reconstruct the evolutionary relationships between organisms, map the functional elements of genomes, and measure gene activity across cells, tissues, and environments. Techniques such as RNA sequencing, sequence alignment, and genome annotation allow researchers to move from raw molecular data to interpretable biological insight, while metagenomics extends this work to entire communities of organisms sampled directly from nature. A central challenge is improving the accuracy and scalability of these computational methods — from assembling fragmented sequence reads into coherent genomes to quantifying subtle variation across millions of transcripts. Active directions include refining phylogenetic inference under complex evolutionary models and developing tools that can handle the enormous sequence diversity uncovered in environmental and clinical samples.

Works

569,628

Total citations

7,604,527

Keywords

RNA-seqsequence alignmentphylogenetic analysisgenome annotationtranscript quantificationmetagenomics assembly