Advanced biosensing and bioanalysis techniques

DNA is far more than a passive carrier of genetic information: researchers now engineer it as a construction material, folding single strands into precise nanoscale shapes or coaxing multiple strands to self-assemble into functional three-dimensional devices. These structures can be coupled with aptamers, nanoparticles, and electrochemical readouts to detect specific molecules — a cancer biomarker, a pathogen, a small drug — with extraordinary sensitivity and selectivity. A central challenge is translating these laboratory demonstrations into robust, deployable diagnostics that perform reliably in complex biological fluids and at clinically relevant concentrations. Active work is pushing toward molecular machines that not only sense a target but respond to it dynamically, as well as multi-signal platforms that reduce false positives by combining orthogonal detection strategies in a single device.

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148,298

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4,410,485

Keywords

DNA nanotechnologyself-assemblybiosensorsaptamersnanoparticleselectrochemistry