Endometrial and Cervical Cancer Treatments

Endometrial and cervical cancers together account for a substantial share of gynecologic malignancies worldwide, and their management has grown considerably more nuanced as researchers distinguish molecularly distinct tumor subtypes that respond differently to surgery, radiation, and systemic therapy. Treatment decisions now draw on tools ranging from robotic-assisted surgery and sentinel lymph node biopsy to brachytherapy and concurrent chemoradiotherapy, each with trade-offs in efficacy, toxicity, and quality of life that remain under active investigation. A central open question is how molecular classification—identifying subgroups such as POLE-mutated or mismatch repair–deficient tumors—should reshape adjuvant therapy recommendations that were historically based on histology and stage alone. Researchers are also working to define which patients can safely avoid aggressive lymph node dissection and how to optimize radiation delivery to reduce long-term pelvic morbidity without compromising disease control.

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Keywords

Endometrial CarcinomaCervical CancerBrachytherapyRadiation TherapyMolecular ClassificationSentinel Lymph Node Biopsy