Carcinogens and Genotoxicity Assessment

Genotoxicity research examines how chemical, physical, and biological agents damage DNA and whether that damage can initiate the chain of mutations leading to cancer. Laboratory tools such as the Comet Assay, which measures strand breaks in individual cells, and the Micronucleus Assay, which detects chromosomal instability, allow researchers to quantify this damage in both controlled experiments and human populations exposed to environmental or occupational hazards. Understanding which exposures are mutagenic—and at what doses—feeds directly into regulatory risk assessment and public health policy. Active work in the area is pushing toward more sensitive biomonitoring approaches that can detect low-level, chronic exposures, and toward mechanistic models that explain why some DNA lesions are efficiently repaired while others persist and drive carcinogenesis.

Works

93,100

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1,693,323

Keywords

Comet AssayGenotoxicity TestingMicronucleus AssayDNA DamageCarcinogenesisEnvironmental Monitoring