Breast Lesions and Carcinomas

Breast pathology examines the structural and cellular changes that give rise to lesions ranging from benign fibroadenomas to invasive carcinomas, relying on imaging modalities like mammography and ultrasound to detect abnormalities and on biopsy with histological analysis to characterize them precisely. Accurate classification matters because treatment decisions—surgery, radiation, systemic therapy—depend on distinguishing, for instance, a phyllodes tumor from a fibroadenoma, or a metaplastic carcinoma from a conventional invasive ductal carcinoma. Researchers are actively working to improve the sensitivity and specificity of screening, reduce overdiagnosis of indolent lesions, and better understand the molecular drivers of rare subtypes like metaplastic carcinoma, which responds poorly to standard chemotherapy. Open questions persist around optimal surveillance intervals for high-risk populations and the biological thresholds that determine when a borderline lesion will progress to frank malignancy.

Works

54,122

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542,180

Keywords

Breast CancerMammographyUltrasoundPathologyLesionsBiopsy