Mesenchymal stem cell research
Mesenchymal stem cells are multipotent cells found in bone marrow, fat tissue, and several other sources that can differentiate into bone, cartilage, muscle, and other tissue types, making them a central focus of regenerative medicine. Beyond their ability to become specialized cells, they also interact with the immune system in ways that may help suppress harmful inflammation, which has driven interest in their use for conditions ranging from heart failure to autoimmune disease. Researchers are actively working to standardize how these cells are isolated and expanded in the lab, since variability in those procedures affects how reliably they perform after transplantation into patients. Key open questions include how long transplanted cells survive and function in the body, and which genetic factors govern their differentiation choices under different physiological conditions.
- Works
- 87,205
- Total citations
- 2,298,255
- Keywords
- Mesenchymal Stem CellsMultipotentRegenerationImmunomodulationTherapeuticDifferentiation
Top papers in Mesenchymal stem cell research
Ordered by total citation count.
- Multilineage Potential of Adult Human Mesenchymal Stem Cells↗ 21,054
- Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors↗ 20,167
- Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement↗ 17,705
- Embryonic Stem Cell Lines Derived from Human Blastocysts↗ 15,911
- The basics of epithelial-mesenchymal transition↗ 10,115OA
- Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies↗ 7,978
- Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA↗ 6,897OA
- Human Adipose Tissue Is a Source of Multipotent Stem Cells↗ 6,652
- RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow↗ 5,531
- National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report↗ 5,388OA
- Bone marrow cells regenerate infarcted myocardium↗ 5,167
- Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)↗ 4,662OA
Active researchers
Top authors in this area, ranked by h-index.