Mesenchymal stem cell research
Mesenchymal stem cells are multipotent cells found in bone marrow, fat tissue, and other sources that can differentiate into bone, cartilage, muscle, and other cell types, making them a focal point for research into tissue regeneration and repair. Beyond their ability to become specialized cells, they also modulate immune responses, which has opened avenues for treating inflammatory and autoimmune conditions as well as supporting transplantation procedures. Researchers are actively working to refine isolation techniques that yield consistent, clinically viable cell populations, and to understand precisely how genetic factors govern differentiation and therapeutic behavior in different disease contexts. Key open questions include how to reliably direct these cells toward specific fates once transplanted, and whether their benefits in conditions like cardiac repair stem primarily from direct tissue integration or from the signaling molecules they release into the surrounding environment.
- Works
- 86,705
- Total citations
- 2,283,074
- Keywords
- Mesenchymal Stem CellsMultipotentRegenerationImmunomodulationTherapeuticDifferentiation
Top papers in Mesenchymal stem cell research
Ordered by total citation count.
- Multilineage Potential of Adult Human Mesenchymal Stem Cells↗ 21,010
- Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors↗ 20,078
- Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement↗ 17,586
- Embryonic Stem Cell Lines Derived from Human Blastocysts↗ 15,869
- The basics of epithelial-mesenchymal transition↗ 10,053OA
- Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies↗ 7,954
- Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA↗ 6,890OA
- Human Adipose Tissue Is a Source of Multipotent Stem Cells↗ 6,633
- RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow↗ 5,530
- National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report↗ 5,325OA
- Bone marrow cells regenerate infarcted myocardium↗ 5,162
- Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)↗ 4,662OA
Active researchers
Top authors in this area, ranked by h-index.