Bone health and osteoporosis research

Osteoporosis is a condition in which bones progressively lose density and structural integrity, making fractures far more likely even from minor falls or everyday stress. Researchers measure this deterioration through bone mineral density scans and microscopic analysis of trabecular architecture, while also investigating the biological signals — including parathyroid hormone, sclerostin, and pathways targeted by drugs like denosumab and zoledronic acid — that govern how bone is built and broken down throughout life. A central challenge is identifying which patients will fracture before it happens, since standard density measurements do not fully capture the complexity of bone quality at the microstructural level. Active work focuses on optimizing treatment sequencing, understanding why some patients lose bone rapidly after stopping certain therapies, and translating insights from sports medicine — where mechanical loading is known to strengthen bone — into clinical strategies for the broader population at risk.

Works

102,371

Total citations

2,297,905

Keywords

FracturesBone Mineral DensityOsteoporotic FracturesMicrostructureDenosumabZoledronic Acid