Asthma and respiratory diseases

Asthma is a chronic inflammatory disease of the airways in which the immune system—particularly cells called eosinophils and the signaling molecules they release—drives recurrent episodes of wheezing, breathlessness, and airflow obstruction. Researchers study how genetic predisposition interacts with environmental triggers to produce distinct disease subtypes, or phenotypes, since patients who appear to share the same diagnosis can differ sharply in their underlying biology and response to treatment. A central challenge is understanding airway remodeling, the structural changes that accumulate over years of inflammation and may permanently reduce lung function even when symptoms are controlled. Active work is focused on identifying which molecular pathways are responsible in each phenotype, with the goal of moving beyond broad anti-inflammatory drugs toward therapies targeted precisely at the mechanisms driving disease in individual patients.

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181,234

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Keywords

AsthmaAllergic DiseasesEosinophilsInflammationImmunologyPhenotypes