Thomas R. Webb

Top papers

• Activating mutations in ALK provide a therapeutic target in neuroblastoma

  Rani E. George, Takaomi Sanda, Megan Hanna, et al.·2008·Nature
  ↗ 889OA
• A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

  Majid Nikpay, Anuj Goel, Hong‐Hee Won, et al.·2015·EUR Research Repository (Erasmus University Rotterdam)
  ↗ 588OA
• The spliceosome is a therapeutic vulnerability in MYC-driven cancer

  Tiffany Hsu, Lukas M. Simon, Nicholas J. Neill, et al.·2015·Nature
  ↗ 520OA
• Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors

  Katerina V. Gurova, Jason E. Hill, Canhui Guo, et al.·2005·Proceedings of the National Academy of Sciences
  ↗ 263OA
• Crystal Structure, Electronic Structure, and Temperature-Dependent Raman Spectra of Tl[Ag(CN)₂]:  Evidence for Ligand-Unsupported Argentophilic Interactions

  Mohammad A. Omary, Thomas R. Webb, Zerihun Assefa, et al.·1998·Inorganic Chemistry
  ↗ 249
• Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy

  Thomas R. Webb, Jake Slavish, Rani E. George, et al.·2009·Expert Review of Anticancer Therapy
  ↗ 230OA
• Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing

  Liying Fan, Chandraiah Lagisetti, Carol C. Edwards, et al.·2011·ACS Chemical Biology
  ↗ 166
• Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A

  Christopher G. Hubert, Robert K. Bradley, Yu Ding, et al.·2013·Genes & Development
  ↗ 153OA
• Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

  Rebecca M. DuBois, P.J. Slavish, Brandi M. Baughman, et al.·2012·PLoS Pathogens
  ↗ 144OA
• Design and Synthesis of a Series of Non-Peptide High-Affinity Human Corticotropin-Releasing Factor₁ Receptor Antagonists

  Chen Chen, Raymond Dagnino, Errol B. De Souza, et al.·1996·Journal of Medicinal Chemistry
  ↗ 137OA
• Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

  Cara Lunn Shirai, Brian S. White, Manorama Tripathi, et al.·2017·Nature Communications
  ↗ 118OA
• Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-<i>a</i>]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

  Chen Chen, Keith Wilcoxen, Charles Q. Huang, et al.·2004·Journal of Medicinal Chemistry
  ↗ 117OA