Richard I. Morimoto

Geroscience: Linking Aging to Chronic Disease

Adapting Proteostasis for Disease Intervention

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

The Biology of Proteostasis in Aging and Disease

Heat shock factors: integrators of cell stress, development and lifespan

Cells in Stress: Transcriptional Activation of Heat Shock Genes

The Biology of heat shock proteins and molecular chaperones.

Autophagy in healthy aging and disease

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.