Neal Rosen

Top papers

• mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

  Kathryn O’Reilly, F. Rojo, Qing‐Bai She, et al.·2006·Cancer Research
  ↗ 2,546OA
• RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

  Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag, et al.·2010·Nature
  ↗ 1,807OA
• RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

  Poulikos I. Poulikakos, Yogindra Persaud, Manickam Janakiraman, et al.·2011·Nature
  ↗ 1,434
• Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

  C. Erec Stebbins, Alicia A. Russo, Christine Schneider, et al.·1997·Cell
  ↗ 1,363OA
• BRAF mutation predicts sensitivity to MEK inhibition

  David B. Solit, Levi A. Garraway, Christine A. Pratilas, et al.·2005·Nature
  ↗ 1,325OA
• Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

  Brett S. Carver, Caren Chapinski, John Wongvipat, et al.·2011·Cancer Cell
  ↗ 1,183OA
• Targeted drug delivery strategies for precision medicines

  Mandana T. Manzari, Yosi Shamay, Hiroto Kiguchi, et al.·2021·Nature Reviews Materials
  ↗ 1,071OA
• AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

  Sarat Chandarlapaty, Ayana Sawai, Maurizio Scaltriti, et al.·2011·Cancer Cell
  ↗ 956OA
• Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

  Rona Yaeger, Walid K. Chatila, Marla Lipsyc, et al.·2018·Cancer Cell
  ↗ 851OA
• Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

  Piro Lito, Martha Solomon, Lian‐Sheng Li, et al.·2016·Science
  ↗ 677OA
• Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function

  Andrea Basso, David B. Solit, Gabriela Chiosis, et al.·2002·Journal of Biological Chemistry
  ↗ 624OA
• ^V600E BRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway

  Christine A. Pratilas, Barry S. Taylor, Qing Ye, et al.·2009·Proceedings of the National Academy of Sciences
  ↗ 613OA