Gregg L. Semenza

Targeting HIF-1 for cancer therapy

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Hypoxia-Inducible Factors in Physiology and Medicine

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

Purification and Characterization of Hypoxia-inducible Factor 1

Regulation of Mammalian O₂Homeostasis by Hypoxia-Inducible Factor 1

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1