Bart De Strooper

Top papers

• Alzheimer's disease

  Philip Scheltens, Kaj Blennow, Monique M.B. Breteler, et al.·2016·The Lancet
  ↗ 3,084
• Reactive astrocyte nomenclature, definitions, and future directions

  Carole Escartin, Elena Galea, András Lakatos, et al.·2021·Nature Neuroscience
  ↗ 2,291OA
• The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

  Eric Karran, Marc Mercken, Bart De Strooper·2011·Nature Reviews Drug Discovery
  ↗ 2,192
• A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

  Bart De Strooper, Wim Annaert, Philippe Cupers, et al.·1999·Nature
  ↗ 2,094
• The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

  Iryna Benilova, Eric Karran, Bart De Strooper·2012·Nature Neuroscience
  ↗ 1,936
• The Cellular Phase of Alzheimer’s Disease

  Bart De Strooper, Eric Karran·2016·Cell
  ↗ 1,907OA
• Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

  Bart De Strooper, Paul Säftig, Katleen Craessaerts, et al.·1998·Nature
  ↗ 1,814
• Microglia states and nomenclature: A field at its crossroads

  Rosa Chiara Paolicelli, Amanda Sierra, Beth Stevens, et al.·2022·Neuron
  ↗ 1,799OA
• OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

  Christian Frezza, Sara Cipolat, Olga Martins de Brito, et al.·2006·Cell
  ↗ 1,633OA
• Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression

  Sébastien S. Hébert, Katrien Horré, Laura Nicolaï, et al.·2008·Proceedings of the National Academy of Sciences
  ↗ 1,170OA
• Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

  Mikael Simons, Patrick Keller, Bart De Strooper, et al.·1998·Proceedings of the National Academy of Sciences
  ↗ 1,157OA
• Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

  Bart De Strooper·2003·Neuron
  ↗ 961OA